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Changes in extratemporal integrity and cognition in temporal lobe epilepsy: A diffusion tensor imaging study

Author(s): Wang Xiang-qing | Lang Sen-yang | Hong L | Lin M | Yan-ling M. A. O. | Yang Fei

Journal: Neurology India
ISSN 0028-3886

Volume: 58;
Issue: 6;
Start page: 891;
Date: 2010;
Original page

Keywords: Diffusion tensor imaging | executive function | temporal lobe epilepsy | thalamus

Background: Diffusion tensor imaging (DTI) is a sensitive technique for studying cerebral white matter. Only a few studies have examined the association between changes in extratemporal integrity and cognition in temporal lobe epilepsy (TLE), especially in Chinese patients. Aim: We used DTI to characterize microstructural changes and investigate their associations with cognition in patients with temporal lobe epilepsy. Patients and Methods: We studied 27 adult patients with TLE and 21 healthy controls. A standardized neuropsychological evaluation and diffusion tensor imaging examination were conducted on each subject. Eight patients were excluded because T2-weighted magnetic resonance imaging (MRI) results showed visible lesions. Furthermore, we determined mean diffusivity (MD) and fractional anisotropy (FA) values in the different regions of interest - normal-appearing white matter (NAWM) in the frontal lobe white matter, the occipital lobe white matter, the corpus callosum, the internal capsules, the external capsules; and normal-appearing gray matter (NAGM) in the caudate nucleus head, the putamens and the thalami. These diffusion measurements were compared between the two groups, and we examined the correlations between DTI values and clinical characteristics. In addition, multiple linear regression analysis was used to study the association of DTI values with cognitive function. Results: Compared with normal controls, TLE patients demonstrated decreased FA in NAGM of both thalami and NAWM of the posterior limb of the left internal capsule (P
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