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Changes of gene expression profile of multiple myeloma cell line RPMI 8226 treated by arsenic trioxide

Author(s): Meng-Chang WANG

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 4;
Issue: 2;
Start page: 160;
Date: 2006;
Original page

Keywords: arsenic trioxide | DNA microarray | multiple myeloma

Objective: To compare the changes of gene expression profiles of multiple myeloma cell line RPMI 8226 before and after 24-hour intervention of arsenic trioxide.Methods: The responses of the RPMI 8226 cells to arsenic trioxide were determined with cDNA microarray which included 4 096 different human genes. Results: Of these 4 096 genes, the expressions of 273 genes were altered significantly at mRNA level. The expressions of 121 genes were up-regulated while the expressions of 152 genes were down-regulated. Conclusion: The effect of arsenic trioxide on RPMI 8226 cells is related to changing the expression levels of a number of genes. ZFYVE16, ALK1 and TXNIP genes may play important roles in apoptosis and differentiation of RPMI 8226 cells.
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