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Changes of pancreatic structure in conditions of an acute pancreatitis modelling

Author(s): Zinenko D.Yu. | Sukhina T.V.

Journal: Морфологія
ISSN 1997-9665

Volume: 4;
Issue: 1;
Start page: 17;
Date: 2010;
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Keywords: pancreas | models of an acute pancreatitis | rat | microcirculation | histostructure

Used various variants of 2 models: 1) model with intraperitoneal introduction L-arginin in dozes 3; 4 and 5 g/kg; 2) model with introduction 50 mkl 1 %-s', 2,5 %-s' and 5 %-s' solutions of sodium taurocholat in a channel of a pancreas. Hystologic research and definition of an amylases level in the blood carried out in 1, 4, 8, 12, 24, 48 and 72 hours after an injection. The lead researches on models with intraperitoneal introduction L-arginin and intrachannel introduction of sodium taurocholat have revealed a similar orientation in development of a sharp pancreatitis on dynamics of an amylases level in the blood and on pathomorphological changes of the parenchyma, stroma and microcirculation in the body. For model with introduction of sodium taurocholat in a channel of a pancreas are more characteristic gemorragycal displays alongside with inflammatory and necrotic changes which have an essential gradient from the head to a tail of the gland. It is observed regenerative dynamics of amylase’s concentration in the blood condition, of microvessels and the general tissue structure of a pancreas of comparison with L-аrginin after application of sodium taurocholat.
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