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CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei

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Author(s): Bienvenu Glinma | Fernand A. Gbaguidi | Salomé D. S. Kpoviessi | Raymond H. Fatondji | Jacques Poupaert | Georges C. Accrombessi

Journal: Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry
ISSN 1582-540X

Volume: 12;
Issue: 1;
Start page: 33;
Date: 2011;
Original page

Keywords: anti-trypanosomal activities | benzophenone | half-inhibitory concentration (IC50) | spectrometrical analysis | substituted thiosemicarbazones

ABSTRACT
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei. Among these compounds, benzophenone 4 phenyl-3-thiosemicarbazone 4 has the highest activity with the half-inhibitory concentration (IC50) = 8.48 micromolar (µM). Benzophenone 4-methyl-3-thiosemicarbazone 3 and benzophenone thiosemicarbazone 1 showed moderate anti-trypanosomal activity with IC50 values equal to 23.27 µM and 67.17 µM respectively. Benzophenone 2 methyl-3-thiosemicarbazone 2 showed no activity up to IC50 = 371.74 µM.
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