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Characterization and biological activities of quercetin thiosemicarbazone derivatives: potential anti cancer drugs

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Author(s): P.V.Subrahmanyam Naidu | Prakash.M.M.S.Kinthada | P.Kalyani | P.Muralidhar

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 03;
Issue: 02;
Start page: 24;
Date: 2012;
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Keywords: Quercetin | Bobgunnia madagascariensis | Flavonoids | Glucosides derivatives | Biological activities

ABSTRACT
Phytochemicals are a fascinating yet mysterious group of thousands of chemicals found in plant foods. Some protect againt cancer, when isolated, some are not associated with cancer at all, and many have yet to be discovered. The phytochemical, quercetin is one of the major dietary flavonoids belonging to a group of flavonols.It occurs mainly as glucosides, but other derivatives of quercetin have been identified as well. Attached substituent’s changes the biological activities of molecules. By investigation, the quercetin 3-o-glucoside and rutin contribute to the relaxation of smooth muscles in mammals and also display chemo preventive nature. Some of recent advances in quercetin derivatives according to characterization and biological activities have been included.

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