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CHARACTERIZATION OF TERNARY SYSTEM OF POORLY SOLUBLE DRUG IN VARIOUS HYDROPHILIC CARRIERS

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Author(s): Vijay Kumar | Shankaraiah MM | Venkatesh JS | Rangaraju D | C.Nagesh

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 143;
Date: 2011;
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Keywords: Fenbendazole(Fbz) | beta-cyclodextrin | PVPK25 | Urea | Mannitol | Dissolution .

ABSTRACT
The present study aims to experiment the solid dispersion of poorly water soluble drug fenbendazole as model drug. Fenbendazole is an Antihelmintic drug (BCS class 2).The purpose of this study was to enhance the dissolution of Fenbendazole by solid dispersions consisting of the drug, a polymeric carrier, Binary and ternary system were prepared by kneading method using hydrophilic polymers like polyvinylpyrrolidone K-25 (PVP K25), beta-cyclodextrin (BCD),mannitol and urea. The prepared formulations were characterized by polymer compatibility by using FT-IR.The drug content uniformity was found to be good in all formulations. The influence of various factors (type of polymer, ratio of the polymer) on the solubility and dissolution rate of the drug were also evaluated. The solubility of fenbendazole was greater with fenbendazole-betacyclodextrin-PVP K-25 system. Dissolution rates of fenbendazole were significantly increased by binary and ternary system. Among all the formulations, fenbendazole-betacyclodextrin-polyvinylpyrrolidone K-25 (VK3) Formulation was found to be better amorphous nature in relation with in-vitro release. The result confirmed that ternary system showed better solubility and dissolution characteristics when compared to binary system.
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