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Chemical and Biological Evaluation of Essential Oil of Teclea nobilis Leaf

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Author(s): Adnan J. Al-Rehaily

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 4;
Issue: 2;
Start page: 166;
Date: 2001;
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Keywords: Teclea nobilis | essential oil | phytochemistry

ABSTRACT
The chemical composition of the essential oil of the leaves of Teclea nobilis Delile (Rutaceae) (TN), was investigated by using GC/MS. Out of fifty four peaks (representing 99.3% of the oil), twenty three components were identified, representing 62.3% of the total oil composition. The main components were Germacrene-d (19%), Ocimene isomer (13%), Guaiol (3.9%), Elemol (2.9%) and Bulnesol (2.5%). Analgesia was evident in both the acetic acid induced writhing and tail flick reaction time tests in mice. A significant antipyretic activity of oil was also observed in mice. A slow and gradual neuromuscular blocking effect was recorded on rat`s phrenic-nerve diaphragm preparation. The oil showed no anti-microbial potential on various microorganisms tested. The oil showed sedative effect on behavioural tests without causing any side effect.
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