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Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis

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Author(s): Pierre Nahon, Angela Sutton, Pierre Rufat, Chantal Simon, Jean-Claude Trinchet, Liliane Gattegno, Michel Beaugrand, Nathalie Charnaux

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 14;
Issue: 5;
Start page: 713;
Date: 2008;
Original page

Keywords: Chemokine | Polymorphism | Cirrhosis | Hepatocarcinoma | Hepatitis C virus

ABSTRACT
AIM: To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 (SDF-1)/CXCL12 and Monocyte Chemotactic Protein-1 (MCP-1)/CCL2, or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma (HCC) occurrence in hepatitis C virus (HCV)-infected patients.METHODS: SDF-1 3’A, MCP-1 (-2518) and CCR5-Δ32 polymorphisms, SDF-1α, Regulated upon Activation Normal T cells Expressed and Secreted (RANTES)/CCL5 and MCP-1 serum levels were determined in 120 HCV-infected patients, included at time of cirrhosis diagnosis and prospectively followed-up.RESULTS: During follow-up, 23/120 (19.1%) patients died and 47/120 (39.1%) developed HCC. Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. The occurrence of death or HCC during follow-up was similar among carriers and noncarriers of each polymorphism. There was no association between the carriage of mutated alleles and chemokine serum levels and the latter were not associated with the risks of death or HCC.CONCLUSION: This study suggests the lack of association of SDF-1 3’A, MCP-1 (-2518), CCR5-Δ32 polymorphisms with death and HCC occurrence in cirrhotic HCV-infected patients.

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