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Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract

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Author(s): Fulya Benzer | Fatih Mehmet Kandemir | Songul Ceribasi | Mustafa Ozkaraca | Nuran Cikcikoglu Yildirim | Sema Temizer Ozan

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 8;
Issue: 1;
Start page: 39;
Date: 2012;
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Keywords: nephrotoxicity | Cisplatin | grape seed extract | rabbit

ABSTRACT
Cisplatin (CP) is one of the most effective cancer chemotherapeutic agent used against various solid tumors. This study was designed to investigate the antioxidant effects of Grape Seed Extract (GSE) on CP induced oxidative damage in rabbit kidney. The material of study was consist of 18 male New Zealand rabbit. Animals were divided into 3 groups. The first group was administered a single intraperitoneal (i.p.) dose of 0.9% saline. The second group of rabbits was treated with CP (a single i.p. dose of 5 mg kg-1 body weight); The third group of rabbits was treated with GSE by gavage at the dose of 250 mg kg-1 body weight for 6 consecutive days before and 6 consecutive days after a single i.p. CP injection. As a result of CP administration, kidney function tests; urea, BUN (Blood Urea Nitrogen) and creatinine levels were increased (p0.05). GSE treatment has high levels of MDA to compared to normal levels (p
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