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CHICKEN EMBRYO: A CARDIOVIDEOGRAM MODEL TO STUDY THE EXPERIMENTAL TOXICITY INDUCED BY Thevetia Peruvians.

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Author(s): Diana Sequera | José Miguel Ercolino | Marco Álvarez

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 28;
Start page: 37;
Date: 2010;
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Keywords: chick embryo | cardiotoxicity | myocardial contractility | cardiovideogram (CVG) | Thevetia Peruvians

ABSTRACT
Studies on the cardiotoxicity induced by chemical agents have been strengthened through the use of cardiogenic signals registration methods. In this study we used a method, defined in our laboratory as Cardiovideogram (CVG), reinforced with image analysis, to illustrate “in vivo” chick embryo heart the cardiotoxicity induced by aqueous extract of Thevetia Peruvians seeds, an ornamental plant with severe toxic action. The results showed that the aqueous extract of Thevetia Peruvians seeds induces Average Heart Rate (AHR) reduction in 70.49% measured in beats per minute (P/ min) through variations of brightness measurement in intervals between the peaks of this variation. These changes were associatedwith a higher Ventricular (V) and Truncus Arteriosus (TA) systolic level and a lower Atrial (A) systole level, compared to the control condition. It was shown that the cardiotoxicity induced by the aqueous extract of Thevetia Peruvians seed can be clearly analyzed in chick embryo cardiac model, strengthened with Cardiovodeogram (CVG) which is an alternative recording method for study of many other toxic agents with cardiotoxic potentially.

Tango Jona
Tangokurs Rapperswil-Jona

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