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Childhood Fibroblastic and Myofibroblastic Tumors: A Multicenter Documentation and Review of the Literature

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Author(s): Ayper KAÇAR | İrem PAKER | Diclehan ORHAN | Aylar POYRAZ | Aylin OKÇU HEPER | Nilüfer ARDA | Esin BODUROĞLU

Journal: Türk Patoloji Dergisi
ISSN 1018-5615

Volume: 28;
Issue: 1;
Start page: 24;
Date: 2012;
Original page

Keywords: Neoplasms | Fibrous tissue | Pediatric | Infant

ABSTRACT
Objective: In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/myofibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject.Material and Method: A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and myofibroblastic group according to World Health Organization criteria were collected.Results: The study comprised 407 soft tissue tumors in total. Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases) of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory myofibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. The only malignant case was an infantile fibrosarcoma.Conclusion: Infantile fibrosarcoma was lower than reported series and a male predominance was noted. The low incidence of newly described entities as well suggests that these tumors may have been unrecognized.
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