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Chimeric Antigen Receptor Therapy for B-cell Malignancies

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Author(s): David L Porter, Michael Kalos, Zhaohui Zheng, Bruce Levine, Carl June

Journal: Journal of Cancer
ISSN 1837-9664

Volume: 2;
Issue: 1;
Start page: 331;
Date: 2011;
Original page

ABSTRACT
We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce rapid and potent anti-tumor activity in chemotherapy refractory CLL patients.

Tango Jona
Tangokurs Rapperswil-Jona

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