Author(s): Castro, E. | A. Soraci | O. Tapia | F. Fogel | R. Franci | L. Denzoin | I. Ortega
Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593
Volume: 5;
Issue: 3;
Start page: 176;
Date: 2006;
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Keywords: Fenoprofen | cats | enantioselective | chiral inversion | carbon tethrachloride
ABSTRACT
The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5?21.1 (mean?sd) and the difference with healthy animals was not statistically significant.
Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593
Volume: 5;
Issue: 3;
Start page: 176;
Date: 2006;
VIEW PDF
DOWNLOAD PDF Original pageKeywords: Fenoprofen | cats | enantioselective | chiral inversion | carbon tethrachloride
ABSTRACT
The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl4). The percentage of chiral inversion in animals with THD was 90.5?21.1 (mean?sd) and the difference with healthy animals was not statistically significant.
