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Chronic consumption of combined extracts of Abelmoschus esculentus and Piper guineense induced hepatoxicity in Wistar rats: Histopathological study

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Author(s): Idorenyin Umoh | Samson Oyebadejo | Eno-obong Bassey | Ukeme Nnah

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 02;
Start page: 73;
Date: 2013;
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Keywords: Abelmoschus esculentus | Piper guineense | Histopathology | Liver | Wistar rat

ABSTRACT
Histopathology of the liver is one of the parameters used in assessing its microstructural integrity. In this study, the effect of the oral chronic exposure of 500mg/kg of Abelmoschus esculentus and 20mg/kg of Piper guineense on the liver of wistar rats was assessed. Twenty adult wistar male rats weighing (123-207g), divided into four groups (Group I-IV), group I as control and groups II, III and IV as treatment groups. The rats in the control group were administered with distilled water, while rats in group II and III were administered with 500mg/kg of Abelmoschus esculentus and 20mg/kg of Piper guineense respectively. Group IV received a combination of the two extracts. After 28days of administration of extracts, animals were sacrificed liver was extracted and processed to paraffin section, cut at 5micron, stained, and observed histopathologically under light microscope. The results showed that exposure to Abelmoschus esculentus and Piper guineense caused cellular proliferation with central vein, portal triad, hepatocytic hyperplasia, radiating from the sinusoidal layer, pyknotic nucleus, nuclear clumping, vascular congestion, vacuolization, degeneration and presence of granulated eosinophilic cells as compared to the control group. Statistical value in the weight of the body and liver showed significant value (p

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