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Chronomodulated drug delivery system of lornoxicam using natural polymers

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Author(s): Ganesh N.S.1,2*, Dr. Deecaraman2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 825;
Date: 2011;
Original page

Keywords: Lornoxicam | controlled release | microspheres | natural polymers.

ABSTRACT
Lornoxicam is an NSAID effectively used in the treatment of arthritis. Being a weak acidic drug it is well absorbed in the lower GIT, and has a short biological half-life of 3-5 hrs. The objective of the present study was to formulate chronomodulated drug delivery system of Lornoxicam to prolong its duration of action and thus reduce the frequency of usage and to minimize its irritant effect on the stomach. Microspheres of Lornoxicam were prepared by emulsification, suspension polymerization and emulsification solvent evaporation techniques by using polymers like Gelatin, NaCMC and Chitosan respectively. In the present study nine formulations were formulated at various drug:polymer ratio. They were subjected to FTIR, SEM, particle size and size distribution, percentage yield, drug content, entrapment efficiency, in vitro dissolution studies and release kinetics. The IR Spectra revealed that, there was no interaction between polymers and drug. Lornoxicam microspheres were spherical in shape, which was confirmed by SEM. Frequency distribution was also obtained. A maximum of 95.75%, 87.68% and 68.40% drug entrapment efficiency was obtained in the Lornoxicam microspheres (Gelatin, Na CMC and Chitosan respectively). Thein vitro performance of Lornoxicam microspheres showed controlled release depending on the polymer concentration. The release kinetics indicated that the release data was best fitted with zero order kinetics. Higuchi equation explains the diffusion controlled release mechanism. The diffusion exponent ‘n’ values of Korsemeyer-Peppa’s model were found to be Non- Fickian. The present study conclusively demonstrates the feasibility of effectively encapsulating Lornoxicam into natural polymers to form potential chronomodulated drug deliverysystem.
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