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CHRONOTHERAPY: A NOVEL DRUG DELIVERY SYSTEM

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Author(s): Dubal Ashwini | Karigar Asif | Ramana MV | Patel Mitul | Desai Omkar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 6;
Start page: 1692;
Date: 2011;
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Keywords: Chronotherapy | circadian rhythm | pulsatile drug delivery system | time controlled chronotropic systems | stimuli induced pulsatile drug delivery systems | externally regulated pulsatile drug delivery systems.

ABSTRACT
Recent advances in chronopharmacology and requirement of an appropriate technology to deliver the drug at specific time and site led to the development of novel type of drug delivery systems as “chronotropic or Pulsatile drug delivery systems”. Rationale behind designing these drug delivery systems is to release the drug at desired time (pathophysiological need of disease), which results into improved therapeutic efficacy and patient-compliance. These systems are meant for treatment of those diseases that are caused due to circadian changes in body like asthma, peptic ulcer, cardiovascular diseases, arthritis and when zero order drug release is not desired. These drug delivery systems are designed to release the drug within a short period of time, immediately after a predetermined lag time. The current article focuses on diseases requiring chronotropic systems and their chronological behavior, various approaches like time controlled chronotropic systems, stimuli induced pulsatile drug delivery systems, externally regulated pulsatile drug delivery systems to design them, recent technologies for chronotherapy and currently available marketed formulations.
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