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Citrullus colocynthis as a bioavailable source of β-sitosterol, antihyperlipidemic effect of oil in rabbits

Author(s): Namama S. TALABANI | Diary I. TOFIQ

Journal: International Journal of Medicinal and Aromatic Plants
ISSN 2249-4340

Volume: 2;
Issue: 3;
Start page: 536;
Date: 2012;
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Keywords: Citrullus colocynthis | β-sitosterol | Hyperlipidemea

A phytochemical study on the seed and kernel of Citrullus colocynthis has been carried out in the present paper. The results revealed the presence of the β-sitosterol in the kernel and seed in different percent (seed contain 16.92% and the kernel contain 6.62%). The lipid lowering active compound (β-sitosterol) has been detected by using TLC, IR, UV and H1-NMR. The present study was designed to reveal the hypocholesterolemic effect of β-sitosterol on the serum total cholesterol and triglyceride in rabbits. Significant drop in serum total cholesterol and triglyceride was observed at 120 h after first administration. These results support the suggestion of Citrullus colocynthis oil as a treatment for hyperlipidemia.
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