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Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

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Author(s): Vanya Slavcheva | T. Lukanov | G. Balatsenko | S. Angelova | А. Antonov | L. Bogdanov | N. Tsvetkov

Journal: Hematology Reports
ISSN 2038-8322

Volume: 2;
Issue: 1;
Start page: e11;
Date: 2010;
Original page

Keywords: Genetics | Klinefelter`s syndrome | Leukemia | Remission

ABSTRACT
Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
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