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Clinical changes in sodium monoiodoacetate–induced stifle osteoarthritis model in dogs

Author(s): N V Goranov

Journal: Veterinary World
ISSN 0972-8988

Volume: 5;
Issue: 3.000;
Start page: 138;
Date: 2012;
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Keywords: dogs | stifle joint | sodium monoiodoacetate | osteoarthritis

In six dogs, experimental model of osteoarthritis (OA) was reproduced by intraarticular injection of sodium monoiodoacetate (MIA) in left stifle joints. Contralateral joints served as control. The clinical status and some goniometric parameters were monitored before MIA introduction and at post injection days 30, 60 and 105. The results showed convincingly that the used experimental chemical OA model reproduced successfully the disease in canine stifle joints. The studied clinical indices correlated with the severity of disease. [Vet. World 2012; 5(3.000): 138-144]
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