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Clinical efficacy of glycosaminoglycans in patients with diabetes mellitus and ischemic heart disease

Author(s): L.V. Kozlova | R.A. Khokhlov | N.M. Akhmedzhanov

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 7;
Issue: 5;
Start page: #;
Date: 2011;
Original page

Keywords: сoronary heart disease | diabetes mellitus | contrast-induced nephropathy | sulodexide.

Aim. To study sulodexide clinical efficacy in patients with type 2 diabetes mellitus (DM) and ischemic heart disease (IHD) in prevention of contrast induced nephropathy (CIN).Material and мethods. Patients with type 2 DM and IHD who undergone X-Ray contrast intervention. The patients were randomized into 2 groups: 56 patients of the main group were i/v administered sulodexide (Vessel Due F, “Alfa Wassermann”, Italy) according to standard procedure; 56 patients of the control group were treated with unfractionated heparin.Results. The incidence of CIN in the main and control groups was, respectively, 16% and 42% (p
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