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Clinical evaluation of anti-hyperglycemic activity of Boerhaavia diffusa and Ocimum sanctum extracts in streptozocin induced T2DM rat models

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Author(s): Dwividendra Kumar Nim | Pratap Shankar | Rakesh Chaurasia | Bhaumic Goel | Narendra Kumar | Rakesh Kumar Dixit

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 01;
Start page: 30;
Date: 2013;
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Keywords: nti-hyperglycemic | Boerhaavia diffusa | Ocimum sanctum | Glibenclamide | T2DM

ABSTRACT
The purpose of this study was to investigate the anti-hyperglycemic effects of daily oral administration of Boerhaavia diffusa (100mm/kg and 200mg/kg) and Ocimum sanctum (200mm/kg and 400mg/kg) extracts for 10 weeks on blood glucose concentration in normal and streptozocin induced type-2 diabetic rats. A significant decrease in blood glucose levels were observed in normal and type-2 diabetic rats treated with Boerhaavia diffusa and Ocimum sanctum extracts, where the order of their anti-hyperglycemic effect is Boerhaavia diffusa (200mg/kg/day)>Ocimum sanctum (400mg/kg/day)>Boerhaavia diffusa (100mg/kg/day)>Ocimum sanctum (200mg/kg/day). A comparison was made between the action of Boerhaavia diffusa and Ocimum sanctum extracts and standard antidiabetic drug-glibenclamide (0.6mg/kg). The effect of glibenclamide was more prominent when compared to Boerhaavia diffusa and Ocimum sanctum extracts, at all the studied doses. In conclusion, our study suggests that both Boerhaavia diffusa and Ocimum sanctum possess anti-hyperglycemic activity, but more studies are needed to elucidate their optimum dose and exact mechanism of action.

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