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Clinical, Parasitological and Immunological Aspects of Experimental Infection with Trypanosoma evansi in Dogs

Author(s): Aquino Lúcia Padilha Cury Thomaz de | Machado Rosangela Zacarias | Alessi Antônio Carlos | Marques Luiz Carlos | Castro Márcio Botelho de | Malheiros Euclides Braga

Journal: Memórias do Instituto Oswaldo Cruz
ISSN 0074-0276

Volume: 94;
Issue: 2;
Start page: 255;
Date: 1999;
Original page

Keywords: Trypanosoma evansi | dogs | biometry | Elisa | inmunofluorescent antibody test | clinical features

This research investigated the pattern of antibody response by means of enzyme linked immunosorbent assay (Elisa) and indirect fluorescent antibody test (IFAT) through the course of experimental Trypanosoma evansi infection in dogs. Clinical and parasitological features were also studied. The average prepatent period was 11.2 days and parasitaemia showed an undulating course. Biometrical study of parasites revealed a mean total length of 21.68mm. The disease was characterized by intermittent fever closely related to the degree of parasitaemia and main clinical signs consisted of pallor of mucous membrane, edema, progressive emaciation and enlargement of palpable lymph nodes. Diagnostic antibody was detected within 12 to 15 days and 15 to 19 days of infection by IFAT and Elisa, respectively. High and persistent antibody levels were detected by both tests and appeared not to correlate with control of parasitaemia

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