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Clinical practice with antidementia and antipsychotic drugs: Audit from a geriatric clinic in India

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Author(s): Prasad Krishna | Gupta Himanshu | Bharath Srikala | Prakash Om | Sivakumar P | Kumar C | Varghese Mathew

Journal: Indian Journal of Psychiatry
ISSN 0019-5545

Volume: 51;
Issue: 4;
Start page: 272;
Date: 2009;
Original page

Keywords: Antidementia drugs | antipsychotics | dementia | prescription pattern

ABSTRACT
Background: Dementia is one of the most disabling disorders afflicting the elderly, with a staggering emotional and economic impact. Antidementia agents have been used for delaying cognitive decline. Antipsychotics are commonly prescribed for behavioral symptoms associated with dementia. Objectives: To explore the use of anti-dementing agents and antipsychotics used in patients with a diagnosis of dementia Materials and Methods: A retrospective chart review method; geriatric clinic of tertiary care setting. Results: The study sample included 51 consecutive patients with a diagnosis of dementia. The commonest subtype of dementia that was diagnosed was Alzheimer′s disease (45%), followed by Frontotemporal dementia (25%).The commonest antidementia drug that was used was donepezil, which alone was prescribed in 27 patients (52%). The commonest antipsychotic used was quetiapine, which was used in 24 patients (47%). Conclusions: The study found donepezil to be the most commonly prescribed antidementia drug and quetiapine to be the most commonly used antipsychotic in a tertiary care geriatric clinic, in a developing country. There is a need to study the cost-effectiveness of antidementia and antipsychotic drugs in patients with dementia, in developing countries.
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