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A Clinical Randomized Trial on Endocervical Inflammatory Cytokines and Betamethasone in Prime-Gravid Pregnant Women at Risk of Preterm Labor

Author(s): Soghra Khazardoust | Pouya Javadian | Bahram Salmanian | Farnaz Zandevakil | Fatemeh Abbasalizadeh | Shohreh Alimohamadi | Sedigheh Borna | Tooba Ghazanfari | Sedigheh Hantoushzadeh

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 3;
Start page: 199;
Date: 2012;
Original page

Keywords: Cytokine | IL-8 | IL-17 | IFN-γ | Preterm Delivery | TGF-β

Background: There are strong evidences suggesting the secretion of different cytokines in cervical fluid during preterm labor. Betamethasone is widely administered for several reasons in preterm conditions. Objective: To Investigate the possible effect of be-tamethasone on endocervical cytokine concentration of women at risk of preterm labor. Methods: In a randomized clinical trial of 80 prime-gravid women in preterm labor be-tween 34 and 37 weeks of gestation, cervical fluid was collected. Endocervical concen-tration of inflammatory cytokines were analyzed before and 48 hours after be-tamethasone treatment for the evaluation of IL-8, IL-17, IFN-γ and TGF-β. Wilcoxon and Mann-Whitney tests were employed for statistical analysis. χ2 and Student’s t tests were used whenever needed. Results: All the measured cytokines showed significant changes in the betamethasone treated group. IL-17 (p=0.001), IL-8 (p=0.001), and IFN-γ (p

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