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Clinical results of the application of a hemoglobin spray to promote healing of chronic wounds

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Author(s): Arenberger, Peter | Engels, Peter | Arenbergerova, Monika | Gkalpakiotis, Spyridon | García Luna Martínez, Francisco Javier | Villarreal Anaya, Americo | Jimenez Fernandez, Laura

Journal: GMS Krankenhaushygiene Interdisziplinär
ISSN 1863-5245

Volume: 6;
Issue: 1;
Start page: Doc05;
Date: 2011;
Original page

Keywords: chronic wounds | hypoxia | hemoglobin | chronic venous insufficiency (CVI) | arterial occlusion | diabetes mellitus

ABSTRACT
A new technological approach for supplying hypoxic chronic wounds with oxygen is a moist wound treatment with aqueous solutions containing tissue compatible oxygen binders. This facilitates diffusion of oxygen, necessary for the healing process, from the surroundings (room air through an open-porous wound padding) into the ulcerous tissue. A product that is still in development is a spray which contains hemoglobin obtained from domestic pigs. Clinical investigations (a clinical trial, treatment observations and single patient uses) are presented, which were performed to create clinical data regarding efficiency and safety of this product. All data have shown that the application of the hemoglobin spray promoted wound healing in all analyzed cases. Data from a clinical study in Mexico and subsequent therapy observations revealed that in 39 out of 42 patients (93%) the treated wounds were healed. 9 patients from a series of therapy observations in Monterrey (Mexico) showed similar observations. All treated wounds were closed. Single patient uses carried out in Witten (Germany; 6 wounds from 8 (75%)) and Prague (Czech Republic; 5 wounds from 5 (100%) were healed) further support these results: The application of hemoglobin spray can promote healing of chronic wounds. Within the framework of the clinical investigation, the treatment observations, and the individual healing experiments the hemoglobin spray was applied more than 2,000 times onto chronic wounds of 82 patients. In all cases, the spray was well tolerated and there were no adverse event that might have been an adverse reaction to the hemoglobin spray.
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