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The Clinical Signifcance of Claudin-7 and Slug Expression 
in Lung Squamous Cell Carcinoma and Adenocarcinoma

Author(s): Rui LI | Daorong ZHANG | Cunwei CAI | Jingyu DONG

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 6;
Start page: 492;
Date: 2011;
Original page

Keywords: Lung neoplasms | Claudin | Slug | Tight junction

Background and objective The aim of this study is to investigate the expression of Claudin-7, Slug and their correltion with clinicopathological characteristics in lung squamous cell carcinoma and adenocarcinoma. We also investigated the relationship between the two factors. Methods The expressions of Claudin-7 and Slug in proteins were detected in 101 cases of lung squamous cell carcinoma and adenocarcinoma samples by immunohistochemistry SP method, and Western blot was applied to detect the expressions of Claudin-7 and Slug in 30 specimens of fresh lung cancer and corresponding paracancerous tissues. Results The expression of Claudin-7 was remarkably decreased in squamous cell carcinoma and adenocarcinoma tissues compared with normal lung tissue, and its expression level was closely correlated with differentiation grade and lymphatic metastasis (P
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