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Clinical significance of P53 and Bcl-2 in acute myeloid leukemia patients of Eastern India

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Author(s): Geetaram Sahu | Rabindra Kumar Jena

Journal: Hematology Reports
ISSN 2038-8322

Volume: 3;
Issue: 3;
Start page: e28;
Date: 2011;
Original page

Keywords: p53 | Bcl-2 | AML | protein expression | survival

ABSTRACT
The frequency of p53 and Bcl-2 protein expression in 100 newly diagnosed and 10 relapsed acute myeloid leukemia (AML) patients was analyzed by immunocytochemistry (ICC). The Kaplan-Meier method was used for univariate and multivariate statistical analysis to assess the relationship between p53, Bcl-2 and clinico-hematologic feature with respect to overall survival (OS) using SPSS statistical software. No statistical significance was found in univariate analysis (P=0.60). However, when the subgroups of patients (+1, +2, +3 and +4) were compared, expression of p53 and Bcl-2 protein (1-10%, 11- 30%, 31-50% and >50%) was statistically significant (P
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