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CLINICAL UTILITY OF INTERFERON- γ RELEASES ASSAYS (IGRAS) IN POTT’S DISEASE

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Author(s): Manoj Kumar, Raj Kumar, AK Srivastava, VL Nag AK Maurya, N Krishnani, TN Dhole and Sunil G Babu*

Journal: International Journal of Bioassays
ISSN 2278-778X

Volume: 2;
Issue: 4;
Start page: 655;
Date: 2013;
Original page

Keywords: IGRAs | Pott’s disease | M. tuberculosis and ATT

ABSTRACT
Interferon-γ release assays (IGRAs) promised a sensitive and specific diagnosis of latent and active infections of Mycobacterium tuberculosis. Therefore, the intent of this study was to appraise the clinical usefulness of Quantiferon-Gold in Tube (QFT-GIT) for diagnosis of Pott’s disease. We prospectively observed 55 clinical radiological suspected cases of Pott’s disease. They were undergone to the detection of tubercular infection by QFT-GIT, microscopy, culture, polymerase chain reaction (PCR) and histopathological methods.  The sensitivity and specificity of QFT-GIT was calculated against the combined results of performed tests. Patients classified into 2 groups as per anti tubercular treatment (ATT), 24 (43.6%) were new cases (group A) and 31 (56.4%) were relapse / on treatment cases (group B). The positivities among group A and B were; 21 (87.5%) and 19 (61.3%) on QFT-GIT, 10 (42%) and 10 (32.2%) on microscopy, 14 (58.3%) and 13 (54%) on culture, 19 (79.2%) and 18 (58%) on PCR, 21 (87.5%) and 18 (58%) on histopathology. The significant positivities differences (p value
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