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Clomiphene citrate challenge test and serum anti-MĂźllerian hormone levels in women with menstrual irregularities and/or infertility.

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Author(s): Tomasz Milewicz | Józef Krzysiek | Barbara Blakała | Magdalena Krzyczkowska-Sendrakowska | Stanisław Radowicki | Olga Kacalska | Marta Zabińska

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 45;
Issue: Suppl 1;
Start page: 119;
Date: 2008;
Original page

ABSTRACT
AIMEvaluation of CCCT results and anti-MĂźllerian hormone (AMH) plasma levels in women with menstrual cycle irregularities and/or infertility.PATIENTS AND METHODS70 patients with menstrual cycle disturbances were recruited to the study. Clomiphene citrate challenge test (CCCT) was carried out in each patient enrolled. At day 3 of the cycle plasma basic levels of FSH, estradiol, progesterone, IGFBP-1, TSH, prolactin, DHEAS and anti-MĂźllerian hormone were measured. At day 10 of the cycle plasma levels of FSH and estradiol were evaluated. Plasma levels of hormones were measured by commercially available ELISA kits.RESULTS50 women with normal result of CCCT (group A) had higher mean plasma level of AMH compared to 20 women with abnormal result of CCCT (group B). Mean plasma FSH level at day 3 of the cycle was lower in group A compared to group B. There were no other statistically significant differences in mean values of assessed parameters between groups A and B. Taking into account all patients enrolled to the study AMH correlated significantly with patients' age and plasma levels of FSH at day 3 and day 10 of the cycle). Basic AMH plasma levels in group A correlated negatively with plasma levels of FSH at day 3 and day 10. In group B plasma levels of FSH at day 10 of the cycle also correlated with basic AMH plasma levels. Plasma levels of estradiol at day 10 of the cycle were related inversely with basic AMH plasma levels in group A, but directly in group B.CONCLUSIONIt should be recommended to perform the CCCT before infertility treatment. Evaluation of the anti-MĂźllerian hormone plasma level reflects the results of the CCCT.
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