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CNS Depressant Effect of the Crude Extract of the Flowering Top of Rosa damascena (Rosaceae)

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Author(s): Mohammad Ashraful Alam | Md. Abu bin Nyeem | Md. Abdul Awal | Mahbub Mostofa | Nusrat Islam | Sheikh Jamal Uddin

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 2;
Start page: 171;
Date: 2006;
Original page

Keywords: Rosa damascena | Depressant activity | Central nervous system

ABSTRACT
The ethanol extract of the flowering top of Rosa damascena (Rosaceae) was assessed for neuropharmacological activities in mice using a number of experimental models. It significantly prolonged the pentobarbitone-induced sleeping time in mice, and showed mild to moderate central nervous system depressant activity when assessed by the hole cross and the open field tests in mice model when given at the doses of 250 and 500 mg/kg body weight. At the same dose levels, the extract dose-dependently inhibited acetic acid-induced writhing in mice. On the basis of these findings, it can be assumed that the extract exerts its depressant effect on the central nervous system in mice.
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