Author(s): Beata Klincewicz | Iwona Igny? | Wojciech Cichy
Journal: Polish Gastroenterology
ISSN 1232-9886
Volume: 14;
Issue: 1;
Start page: 23;
Date: 2007;
Original page
ABSTRACT
Introduction: Celiac disease named "gluten enteropathy" is immunogenetic disorder resulting from congenital and longlife staying gluten intolerance, especially its gliadin fraction and other prolamins. Coexistence of celiac disease with other autoimmune disorders like autoimmune thyroid disease, gastritis, inflammatory bowel disease (IBD) is underlined in medical literature. Aim of study: Aim of this paper was to establish if there is any coexistance of celiac disease in children with IBD. Material and methods: 136 children with IBD recognized in years 2000-2005 were enrolled in the study: 49 cases with Crohn's disease (CD), 87 cases with ulcerative colitis (UC). Serological tests to detect EmA IgA, EmA IgG were performed in all patients. In those with positive EmA results gastroduodenoscopy with duodenal biopsy was carried out. Duodenal biopsy samples were assessed acc.to Marsh Scale and immunochemistry was done to find intraepithelial lymphocytes. Results: Among 49 patients with CD, celiac disease was revealed in 4 cases. In 1 child celiac disease appeared 2 years earlier than IBD. 2 children/87 with UC developed celiac disease. In 1 case it was recognized in the same time as UC, in the second patient after 1.5 yearof colitis duration. Conclusions: Our study confirms the hypothesis that there is association of celiac disease and IBD.
Journal: Polish Gastroenterology
ISSN 1232-9886
Volume: 14;
Issue: 1;
Start page: 23;
Date: 2007;
Original page
ABSTRACT
Introduction: Celiac disease named "gluten enteropathy" is immunogenetic disorder resulting from congenital and longlife staying gluten intolerance, especially its gliadin fraction and other prolamins. Coexistence of celiac disease with other autoimmune disorders like autoimmune thyroid disease, gastritis, inflammatory bowel disease (IBD) is underlined in medical literature. Aim of study: Aim of this paper was to establish if there is any coexistance of celiac disease in children with IBD. Material and methods: 136 children with IBD recognized in years 2000-2005 were enrolled in the study: 49 cases with Crohn's disease (CD), 87 cases with ulcerative colitis (UC). Serological tests to detect EmA IgA, EmA IgG were performed in all patients. In those with positive EmA results gastroduodenoscopy with duodenal biopsy was carried out. Duodenal biopsy samples were assessed acc.to Marsh Scale and immunochemistry was done to find intraepithelial lymphocytes. Results: Among 49 patients with CD, celiac disease was revealed in 4 cases. In 1 child celiac disease appeared 2 years earlier than IBD. 2 children/87 with UC developed celiac disease. In 1 case it was recognized in the same time as UC, in the second patient after 1.5 yearof colitis duration. Conclusions: Our study confirms the hypothesis that there is association of celiac disease and IBD.
