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COLLAGEN FOR U.I. MINIMAL DOSE INJECTIONS IN SCHEDULED STEPS TO IMPROVE CLINICAL RESULTS

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Author(s): F. Mantovani | A. Del Nero | S. Confalonieri | E. Pisani

Journal: Urogynaecologia International Journal
ISSN 1121-3086

Volume: 16;
Issue: 1;
Start page: 29;
Date: 2010;
Original page

Keywords: incontinence | collagen | bulking agents

ABSTRACT
Endoscopic treatment of urinary incontinence is based on the use of injectables. We use collagen (Contigen-Bard) to make the bladder neck narrower in order to ensure dynamic continence and avoid obstruction. Gax collagen is highly purified, hardly viscous bovine dermal collagen, cross-linked with glutaraldehyde in saline solution. The possible approaches for the endoscopic collagen implant are: perineal, paraurethral and transurethral, which is our choice. We are in favour of repeated injections in scheduled steps with a minimal dose: 5 ml injected transurethrally in the positions 5 and 7 every 2 months, three times: 24 patients (18 women and 6 men) average age 58, underwent the treatment and were checked with a twelve months follow-up. Effectiveness was complete in 12 women and 3 men, a significant improvement of the quality of life was reported in the other patients.
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