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Colon targeting drug delivery system: A review on recent approaches

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Author(s): K.V. Vinay Kumar | T. Sivakumar | T. Tamizh mani

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 02;
Issue: 01;
Start page: 11;
Date: 2011;
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Keywords: Colon targeted drug delivery | Microbially triggered | pH sensitive | Time controlled dependent | Pressure controlled | Osmotically controlled | Pulsatile drug delivery system

ABSTRACT
Article reviews the surge of research focus, potential opportunities and challenges available in new area of colon targeted drug delivery system. Colon was considered as “BLACK BOX” as, most of drugs are absorbed from upper part of GIT tract. Lack of digestive enzymes and long transit time, has been provided to design colon specific drug delivery system and review is aimed at understanding recent advancements made in multiparticulate formulation approaches, matrix, multilayer and compression coated tablets to reach colon intact to be investigated by approaches for targeting through pH sensitive system, Microbially triggered system i.e., prodrugs and polysaccharide based system, Timed release system, osmotically controlled drug system, pressure dependent release system, programmed pulsatile release system etc., Although oral delivery has become a widely acceptable route of administration, GI tracts presents several formidable barrier to drug delivery. In addition life cycle management, patient compliance, improved stability and optimisation of drug absorption process are some key drivers for developing alternative delivery system of drugs.

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