Academic Journals Database
Disseminating quality controlled scientific knowledge

The combination effect of curcumin with different antibiotics against Staphylococcus aureus

Author(s): Moghaddam Kamyar | Iranshahi Mehrdad | Yazdi Mahsa | Shahverdi Ahmad

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 3;
Issue: 2;
Start page: 141;
Date: 2009;
Original page

Keywords: Antibacterial activity | combination effect | Staphylococcus aureus | curcumin

The different investigation has been carried out on the biological activities of curcumin but the effect of this natural product on the antibacterial activity of different antibiotics has not been demonstrated. In this study the enhancement effect of curcumin on the antibacterial activity of different antibiotics was evaluated against Staphylococcus aureus. Disk diffusion method was used to determine the antibacterial activity of these antibiotics in the absence and presence of sub inhibitory concentration of curcumin. A clinical isolate of S. aureus was used as test strain. In the presence of sub-inhibitory concentration of curcumin (500 µg/disc) the antibacterial activities of cefixime, cephotaxime, vancomycin and tetracycline have been increased against test strain. The highest fold increase in area was observed for cefixime against S. aureus (a 52.6 % increase in inhibition zone surface area). Also the increases in inhibition zone areas (%) for cephotaxime, vancomycin and tetracycline were 24.9%, 26.5% and 24.4%, respectively. No enhancing effect on the antibacterial activities of others antibiotics was detected against S. aureus at content of 500µg/disc. Conversely, in case of nalidixic acid, curcumin showed an antagonistic effect on the antibacterial activity of this antibiotic against test strain. These results signify that the curcumin potentiates the antimicrobial action of cefixime, cephotaxime, vancomycin and tetracycline suggesting a possible utilization of this edible compound in combination therapy against S. aureus.
Why do you need a reservation system?      Affiliate Program