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Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

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Author(s): Riggio Cristina | Ciofani Gianni | Raffa Vittoria | Cuschieri Alfred | Micera Silvestro

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 4;
Issue: 7;
Start page: 668;
Date: 2009;
Original page

Keywords: Vertically aligned carbon nanotubes | Drug delivery | Alginate | NGF | PC12 cells

ABSTRACT
Abstract In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

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