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Combination of thrombophilia markers in acute myocardial infarction of the young

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Author(s): Khare Amit | Ghosh Kanjaksha | Shetty Shrimati | Kulkarni Bipin | Mohanty Dipika

Journal: Indian Journal of Medical Sciences
ISSN 0019-5359

Volume: 58;
Issue: 9;
Start page: 381;
Date: 2004;
Original page

Keywords: Homocysteine | Fibrinogen | Combined thrombophilia | Myocardial infarction | India

ABSTRACT
BACKGROUND: The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental factors related to atherosclerosis and thrombosis. But, there have been very few studies in India which have investigated some of the thrombophilia markers. AIM: To look for combined thrombophilia in MI patients. SETTINGS AND DESIGN: One hundred twenty patients of myocardial infarction (age below 40 yrs.) were recruited 8-10 weeks after stabilization. Hundred age and sex-matched healthy controls were also recruited in the present study. METHODS AND MATERIAL: Following thrombophilia markers were screened in these patients- plasma fibrinogen, protein C, protein S, antithrombin III, factor V Leiden, PT G20210A polymorphism, MTHFR C677T, homocysteine, fibrinogen b448 Arg/Lys polymorphism and CBS T833C mutation. STATISTICAL ANALYSIS: Statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 10.0, SPSS Inc., Chicago, USA. RESULTS AND CONCLUSION: Elevated fibrinogen levels, homocysteine (p
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