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Combined Leucopenia and Thrombocytopenia Are Possibly Adverse Events of Lamotrigine

Author(s): H. A. Ebrahimi | M. J. Zahedi

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 9;
Issue: 1;
Start page: 35;
Date: 2010;
Original page

Keywords: Lamotrigine | Epilepsy | Hematological Side Effects | Leucopenia | Thrombocytopenia | Combined Leucopenia and Thrombocytopenia

Hematological side effects are rare with lamotrigine. We report two cases (two men; 46 years old and 65 years old) with epilepsy that developed combined leucopenia and thrombocytopenia after receiving low dose lamotrigine for a time. Three weeks after discontinuing lamotrigine, all of the hematological abnormalities disappeared. We suggest that combined leucopenia and thrombocytopenia is one of the side effects of lamotrigine that must be considered.

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