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A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses

Author(s): Azizi Ali | Aucoin Susan | Tadesse Helina | Frost Rita | Ghorbani Masoud | Soare Catalina | Naas Turaya | Diaz-Mitoma Francisco

Journal: Genetic Vaccines and Therapy
ISSN 1479-0556

Volume: 3;
Issue: 1;
Start page: 7;
Date: 2005;
Original page

Keywords: Vaccine | SARS | Nucleocapsid | XIAP

Abstract Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.
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