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Comparative analysis of serum protein electrophoresis’ ‎profiles of people infected with HIV and those not infected ‎with HIV in Kinshasa

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Author(s): KAMANGU NTAMBWE ERICK | KALALA LUNGANZA RICHARD | MVUMBI LELO ‎GEORGES | MESIA KAHUNU GAUTHIER

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 4;
Issue: 6;
Start page: 876;
Date: 2012;
Original page

Keywords: hyperprotidemia | hypergammaglobulinemia | hypoalbuminémie | total proteins | HIV

ABSTRACT
Introduction: It is necessary to consider the analysis of electrophoresis’ profiles of serum ‎proteins as an alternative and less expensive for the biological monitoring of patients infected by ‎HIV in countries with limited resources.‎Objective: The aim of the study was to establish a comparison between the electrophoresis’ ‎profile of sera proteins of people infected by HIV naïve of treatment and people not infected by ‎HIV. ‎Method: A transversal study was conducted at AMO-CONGO Kasa-Vubu in Kinshasa with ‎people who came for a voluntary HIV screening test. Eighty one people, naïve of HAART, ‎participated voluntarily in the study. HIV screening was systematically done according to WHO ‎recommendations. Blood sample was obtained in a dry tube for the electrophoresis’ profile of ‎sera proteins, and in a tube with EDTA for numeration of CD4 for HIV positive patients. The ‎statistical test of Chi-squared was used for qualitative data, and the test of Student for ‎quantitative data.‎Result: Out of 81 volunteers, 30 were confirmed HIV positive and 51 negative. The results ‎obtained demonstrate that HIV infection is associated with a hyperprotidémie (60%), a ‎hypoalbuminémie (100%) also a hypergammaglobulinemia (100%) according to CD4 level. No ‎significant modification was observed for the alpha and beta-globulins.‎Conclusion: The HIV infection induces some significant modifications of different fractions of ‎sera proteins according to immune status.‎
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