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Comparative Efficacy of Neem and Karela with Insulin and Glibenclamide on Lipid Profile in Rabbit (Oryctolagus cuniculus)

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Author(s): Ahmed, S. | M. A. Awal | M. M. Rahman | M. Mostofa

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 4;
Issue: 1;
Start page: 103;
Date: 2005;
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ABSTRACT
Comparative efficacy of neem and karela with insulin and glibenclamide was studied on some lipid profile(total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol) in 40 rabbits from February to April, 2003. Rabbits were randomly divided into 8 equal groups and rabbits of group A and B were kept as non hyperglycemic control and hyperglycemic control respectively. Hyperglycemia was induced in 7 groups of rabbits (B, C, D, E, F, G and H) by administering alloxan at a dose of 200 mg/ kg body wt. s/c. After 15 days of alloxan injection, 6 groups of rabbits (C, D, E, F, G and H) were treated with insulin, glibenclamide, neem seed kernel powder (NP), neem seed oil (NSO), neem leaf extract (NLE) and karela fruit juice (KFJ) at the dose rate of 5 U/kg, 0.5 mg/ kg., 500 mg/kg , 1 ml/kg , 500 mg/ kg and 100 mg/kg body weight respectively for consecutive 28 days. All the control and treated rabbits were closely observed during pre-treatment, 28 days of treatment and also for 14 days of post-treatment period and the lipid profile was investigated. Due to alloxan induced diabetes the content of total cholesterol increased significantly (P
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