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Comparative Evaluation of Alcoholic and Aqueous Extracts of Ocimum Sanctum for Immunomodulatory Activity

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Author(s): J. Vaghasiya, | M. Datani, | K. Nandkumar | S. Malaviya | N. Jivani

Journal: International Journal of Pharmaceutical and Biological Research
ISSN 0976-285X

Volume: 1;
Issue: 1;
Start page: 25;
Date: 2010;
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Keywords: Ocimum sanctum | immunomodulatory activity | HA titer | DTH

ABSTRACT
Background: Traditionally the aqueous and alcoholic extracts as well as seed oil of Ocimum sanctum is reported to modulate the immune response. So the present study was undertaken to compare the immunomodulatory activity between alcoholic and aqueous extract of Ocimum sanctum. Objective: To comparatively evaluate the mmunomodulatory activity of alcoholic and aqueous extracts of Ocimum sanctum. Methods: Alcoholic and aqueous extracts of Ocimum sanctum were administered orally at doses of 50, 100 and 200 mg/kg/day for 14 days to healthy albino Swiss mice. The assessment of immunomodulatory activity was carried by testing the humoral (haemagglutination antibody titer model) and cellular immunity (delayed type hypersensitivity reaction models). Results: On oral administration of aqueous and alcoholic extracts had stimulatory effect on delayed typehypersensitivity (DTH) and significantly (p
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