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Comparative evaluation of lornoxicam microspheres using natural and synthetic polymers

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Author(s): Ganesh N.S.1,2*, Dr. Deecaraman2, Dr. Vijayalakshmi2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3212;
Date: 2011;
Original page

Keywords: Lornoxicam | Controlled release | Microspheres | Natural polymers | Synthetic polymers.

ABSTRACT
Lornoxicam is an effective NSAID used in the treatment of arthritis. Being a weak acidic drug it is well absorbed in the lower GIT, and has a short biological halflifeof 3-5 hrs. The objective of the present study was to formulate a controlled drug delivery system of Lornoxicam to prolong its duration of action, reduce thefrequency of dosage and to improve patient compliance. Microspheres of Lornoxicam were prepared by using natural and synthetic polymers, viz., NaCMC andEudragit respectively. In the present study three formulations each were formulated at various drug:polymer ratios. They were subjected to FTIR, SEM, particlesize, size distribution, percentage yield, drug entrapment efficiency, in vitro dissolution studies and release kinetics. The IR Spectras revealed that there was nointeraction between the drug and polymers. The formulated Lornoxicam microspheres were spherical in shape which was confirmed by SEM. A maximum of98.38%, and 87.68% drug entrapment efficiency were obtained in the Lornoxicam microspheres (NaCMC and Eudragit respectively). The in vitro performanceof Lornoxicam microspheres showed controlled release depending on the polymer concentration. The release kinetics indicated that the release data was best fittedto zero order kinetics. Higuchi equation explains the diffusion controlled release mechanism. The diffusion exponent ‘n’ values of Korsemeyer-Peppa’s model werefound to be Non-Fickian with both the polymers. The present study conclusively demonstrates the feasibility of effectively encapsulating Lornoxicam into naturaland synthetic polymers to form potential controlled drug delivery systems, however the synthetic polymer weighing slightly above the natural polymers in mostof the formulation parameters.
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