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Comparative in-vitro release profile of formulated microparticles containing indomethacin using synthetic and natural polymer (Gum Karaya)

Author(s): Girraj Tyagi1*, Jyotirmoy Deb1, Amitava Ghose1, Amitav Roy1, Braj Kishor Tiwari1, Radha Raman Tiwari1, Faizi Muzaffar2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2123;
Date: 2011;
Original page

Keywords: Indomethacin | Gum karaya | Hydroxypropyl methyl cellulose | Emulsion solvent evaporation technique | Microspheres.

The ability to deliver drugs to the target site is feasible over the years. In the present study, microspheres of Indomethacin (IM), which is a non steroidal anti inflammatory drug (NSAIDs) employing Gum karaya (GK) as the hydrophilic carrier, prepared by emulsion solvent evaporation technique which will provide prolong the release. Gum karaya is dried gummy exudates obtained from the tree Sterculia urens (Roxburgh). Microspheres containing Indomethacin (IM) wereprepared by emulsion solvent evaporation method by using hydroxypropyl methyl cellulose (HPMC) and Gum karaya (GK) as rate controlling polymer. The prepared microspheres were characterized by particle size, percentage yield, entrapment efficiency, micromaritic properties, in-vitro release behavior, scanning electron microscopy (SEM), FTIR etc. The in-vitro release studies was performed by buffer change method to mimic Gas Intestine Tract (GIT) environment in 0.1 N HCL, carbonate buffer (acidic) and pH 7.4, phosphate buffer (Alkaline). The prepared microspheres were pale yellow, free flowing and spherical in shape. The mean particle size of the microspheres was found in the range of 289 to 384 μm. The drug-loaded microspheres show high entrapment efficiency (72.4%) and release was extended up to 6 to 8 hours releasing 90% of the total drug from the microspheres. The infrared spectra showed stable character of Indomethacin in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy studyrevealed that the microspheres were spherical and porous in nature. It was concluded that the gum possess substantial release controlling properties that could be used for sustained drug delivery.
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