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Comparative Pharmacokinetics of Intramuscular Ceftriaxone Co-Administered with Acetaminophen in Healthy and Infected Sokoto Red Goats

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Author(s): Abdulgafar O. Jimoh | Shaibu O. Bello | Emmanuel U. Etuk | Solomon A. Adeleye | Vincent U. Igbokwe

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 7;
Issue: 5;
Start page: 623;
Date: 2011;
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Keywords: acetaminophen | ceftriaxone | Pharmacokinetics | Sokoto red goat | Salmonella thyphimurium

ABSTRACT
This study was aimed at finding out if paracetamol influences the pharmacokinetics of ceftriaxone in healthy and salmonella thyphimurium infected Sokoto red goats. In a randomised three-way study, 15 healthy male goats weighing 10-13 kg were divided into three groups of five goats each and each group got either a single intramuscular dose of 1 g ceftriaxone only, 1 g ceftriaxone co-administered with 300 mg paracetamol or 1 g ceftriaxone co-administered with 300 mg paracetamol plus inoculation with Salmonella thyphimurium. Non compartmental Pharmacokinetic parameters were measured in plasma samples by microbiological assay. There was a statistically significant (p
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