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A Comparative Study Between Alcoholics of Koraga Community, Alcoholics of General Population and Healthy Controls for Antioxidant Markers and Liver Function Parameters

Author(s): Mungli Prakash | Naureen Anwar | Prasiddha Tilak | Mahesh S Shetty | Lakshmi S Prabhu | Vivekananda Kedage | Manjunatha S Muttigi | Virupaksha Devaramane | Panambur V Bhandary

Journal: Online Journal of Health & Allied Sciences
ISSN 0972-5997

Volume: 8;
Issue: 4;
Date: 2010;
Original page

Keywords: Koraga | alcoholics | total thiols | GST | cirrhosis | antioxidant status

Objectives: It is well established that long-term alcohol consumption leads to liver cirrhosis and other related disorders. Sufficient work has been done on biochemical markers of liver damage and antioxidant status of chronic alcoholics in general population. In the current study chronic alcoholics from a community called Koraga are analysed for the same parameters in a view to assess the extent of liver damage as compared to healthy controls and other alcoholics. Methods: Serum and urine samples from Koraga alcoholics (n=28), general alcoholics (n=30) and healthy controls (n=31) were analysed for liver function parameters and antioxidant markers. Liver function parameters were determined by automated analyzer. Markers of antioxidant status were estimated spectrophotometrically. The data was analysed using SPSS version 16.0. Results: There was significant increase in serum AST, serum ALT, serum GST and urine GST in both general and Koraga alcoholics when compared to healthy controls (p
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