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A Comparative Study of Bolus Administration and Continuous Infusion of Ranitidine on Gastric PH With Intragastric PH-Probe

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Author(s): Mojtaba Mojtahedzadeh | Mansoor Rastegarpanah | Reza Malekzadeh | Hossein Khalili | Mohammed Reza Ganji MD | Khairollah Gholami

Journal: DARU : Journal of Pharmaceutical Sciences
ISSN 1560-8115

Volume: 10;
Issue: 4;
Start page: 153;
Date: 2002;
Original page

Keywords: Gastric pH monitoring | pH probe | Stress related mucosal damage | Intensive care unit | Bolus | Continuous infusion

ABSTRACT
The high mortality rate associated with significant bleeding from stress ulceration has promoted efforts to prevent this complication in critically ill patients. Gastric pH is a key factor in the pathogenesis of stress ulceration and maintaining a pH of 4 or greater reduces the risk for development of the gastric ulceration. Our aim was to compare effects of intravenous bolus administration and continuous intravenous infusion of ranitidine on gastric pH in critically ill patients at the intensive care unit (ICU). Twenty patients who met the inclusion criteria were entered this prospective, randomized, cross over study. A total of 1500 gastric pH measurement was obtained for each phase of the study. Continuous infusion of ranitidine maintained a gastric pH greater than 4 over a longer period than that of bolus administration (22.1 hrs vs. 14.2 hrs, respectively; P
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