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COMPARATIVE STUDY OF CIRRHOTIC PATIENTS AND PORTAL VEIN THROMBOSIS – WITH OR WITHOUT ASSOCIATED HEPATOCARCINOMA

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Author(s): Mirela Ionescu, | M. Ciocîrlan, | V. Stog, | M.M. Diculescu

Journal: Jurnalul de Chirurgie
ISSN 1584-9341

Volume: 7;
Issue: 3;
Start page: 401;
Date: 2011;
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Keywords: PORTAL VEIN THROMBOSIS | CIRRHOSIS | HEPATOCARCINOMA

ABSTRACT
Portal vein thrombosis (PVT) is a dramatic complication which may appear in liver cirrhosis. Our aim was to identify the factors associated with PVT in cirrhotic patients without hepatocarcinoma (HCC) in comparison with those with liver cancer. Methods: All adult patients with liver cirrhosis and PVT recorded in the database of Elias Hospital between January 2008 and March 2010 were included. We excluded thrombhophilic disorders. HCC diagnosis was done according to Barcelona criteria. We included 42 patients with PVT, 28 patients with HCC and 14 patients without. Results: Child-Pugh class C was significantly more frequently encountered in HCC patients, 18/28 patients (64.3%) with HCC compared with 2/14 patients (14.3%) without HCC. Alanine amino-transferase(ALT), aspartic amino-transferase(AST) and gamma-glutamyl trans-peptidase(GGT) levels were significantly higher in the HCC group. A history of splenectomy and gallstones were significantly less frequently seen in HCC patients. CLIP score was quite high in our group, with a score of 4 to 6 in 67.9% of cases, with a predicted median survival of 3.2months, 0% at 2 years. Conclusion: Severity of underlying liver cirrhosis and serum enzyme levels are significantly higher in patients with cirrhosis and portal vein thrombosis associated HCC.
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