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A comparative study of efficacy and tolerability of antianginal drugs of different groups — nitrovasodilatator (isosorbide-5-mononitrate sustained release) and beta-blocker with vasodilating action (nebivolol) — in patients with stable angina

Author(s): S.Yu. Martsevich | N.P. Kutishenko | V.A. Egorov | A.V. Zagrebel'nyy | A.A. Serazhim | Yu.V. Lukina | N.A. Dmitrieva

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 7;
Issue: 5;
Start page: 555;
Date: 2011;
Original page

Keywords: beta-blocker | isosorbide-5-mononitrate | antianginal efficacy | ischemic heart disease | exercise tolerance test | side effects.

Aim. To compare the efficacy and safety of the slow-release isosorbide-5-mononitrate and of the nebivolol in patients with stable angina.Material and methods. Patients (n=19) with ischemic heart disease (stable angina) were enrolled into randomized, double-blind, placebo-controlled, crossover study. They alternatively received nebivolol 5 mg QD or slow-release isosorbide-5-mononitrate 50 mg QD. The drug efficacy was assessed by changes in symptoms, angina attack number, sublingual nitroglycerin need, and treadmill test duration.Results. Patients treated with isosorbide-5-mononitrate shown significant increase in heart rate (HR) at rest in all time check-points in comparison with patients receiving placebo. HR significantly decreased 2 hours after nebivolol intake both single one and after 30 days of treatment (p
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