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A comparative study of nebivolol and (S) atenolol on blood pressure and heart rate on essential hypertensive patients

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Author(s): Sahana G | Sarala N | Kumar T | Lakshmaiah V

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 42;
Issue: 6;
Start page: 401;
Date: 2010;
Original page

Keywords: Essential hypertension | nebivolol | (S)-atenolol

ABSTRACT
Objectives: To study the effect of nebivolol 5 mg once daily versus (S)-atenolol 25 mg once daily in patients with essential hypertension. Materials and Methods: A prospective study was conducted at RLJH and Research Centre which included 30 patients in each group with essential hypertension. The sex, age, presenting illness, and family history of the patients were recorded. Investigations such as blood sugar, urine analysis, kidney function test, lipid profile, and ECG were performed before starting the treatment. Any adverse effects during the treatment were noted. Blood pressure and heart rate were recorded at baseline and during follow-up. One group received nebivolol 5 mg once daily and other group (S)atenolol 25 mg once daily. Patients were followed-up every 15 days for 3 months. Results: Nebivolol group had 18 males and 12 females with mean age 50.6 ± 9.5 years, (S)-atenolol had 16 males and 14 females with mean age 54.4 ± 9 years. Patients receiving nebivolol and (S)-atenolol showed a significant fall (P
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