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A comparative study on the efficacy of rectal diazepam and midazolam for reduction of pre-operative anxiety in pediatric patients

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Author(s): Seyed Mohammad Mireskandari; Seyed Mohammad-Bagher Akhavirad; Mohammad-Esmaiel Darabi; Reza Alizadeh

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 17;
Issue: 2;
Start page: 157;
Date: 2007;
Original page

Keywords: Rectal diazepam | Rectal midazolam | Premedicant | Elective operation

ABSTRACT
Objective: Children, due to their great parental dependency, are amongst the cases that should receive preoperatively medication to reduce their fear and anxiety. The objective of this study was to compare the efficacy of rectal diazepam and midazolam for this purpose in pediatric patients scheduled for elective surgery. Material & Methods: 60 children, aged between 1 and 6 years, scheduled for elective surgery, were included in this double blind, randomized controlled trial. Patients were randomly allocated into three equal groups. Patients in midazolam and diazepam groups received the drugs 0.3 mg/kg and 0.5 mg/kg respectively (in normal saline at a final volume of 2.5 ml) and placebo group received only 2.5 ml of normal saline 20 min before arriving operation room through rectal applicator. Sedation and anxiety scores at the time of separation from their parents before arriving operating room were recorded for all groups. Findings: There was a significant reduction in anxiety level in midazolam and diazepam groups as compared to placebo group (P

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